Membrane alterations induced by nonstructural proteins of human norovirus
Identifieur interne : 000816 ( Main/Exploration ); précédent : 000815; suivant : 000817Membrane alterations induced by nonstructural proteins of human norovirus
Auteurs : Sylvie Y. Doerflinger [Allemagne] ; Mirko Cortese [Allemagne] ; Inés Romero-Brey [Allemagne] ; Zach Menne [Allemagne] ; Thibault Tubiana [France] ; Christian Schenk [Allemagne] ; Peter A. White [Australie] ; Ralf Bartenschlager [Allemagne] ; Stéphane Bressanelli [France] ; Grant S. Hansman [Allemagne] ; Volker Lohmann [Allemagne]Source :
- PLoS Pathogens [ 1553-7366 ] ; 2017.
Abstract
Human noroviruses (huNoV) are the most frequent cause of non-bacterial acute gastroenteritis worldwide, particularly genogroup II genotype 4 (GII.4) variants. The viral nonstructural (NS) proteins encoded by the ORF1 polyprotein induce vesical clusters harboring the viral replication sites. Little is known so far about the ultrastructure of these replication organelles or the contribution of individual NS proteins to their biogenesis. We compared the ultrastructural changes induced by expression of norovirus ORF1 polyproteins with those induced upon infection with murine norovirus (MNV). Characteristic membrane alterations induced by ORF1 expression resembled those found in MNV infected cells, consisting of vesicle accumulations likely built from the endoplasmic reticulum (ER) which included single membrane vesicles (SMVs), double membrane vesicles (DMVs) and multi membrane vesicles (MMVs). In-depth analysis using electron tomography suggested that MMVs originate through the enwrapping of SMVs with tubular structures similar to mechanisms reported for picornaviruses. Expression of GII.4 NS1-2, NS3 and NS4 fused to GFP revealed distinct membrane alterations when analyzed by correlative light and electron microscopy. Expression of NS1-2 induced proliferation of smooth ER membranes forming long tubular structures that were affected by mutations in the active center of the putative NS1-2 hydrolase domain. NS3 was associated with ER membranes around lipid droplets (LDs) and induced the formation of convoluted membranes, which were even more pronounced in case of NS4. Interestingly, NS4 was the only GII.4 protein capable of inducing SMV and DMV formation when expressed individually. Our work provides the first ultrastructural analysis of norovirus GII.4 induced vesicle clusters and suggests that their morphology and biogenesis is most similar to picornaviruses. We further identified NS4 as a key factor in the formation of membrane alterations of huNoV and provide models of the putative membrane topologies of NS1-2, NS3 and NS4 to guide future studies.
Url:
DOI: 10.1371/journal.ppat.1006705
PubMed: 29077760
PubMed Central: 5678787
Affiliations:
- Allemagne, Australie, France
- Bade-Wurtemberg, District de Karlsruhe, Nouvelle-Galles du Sud
- Heidelberg, Sydney
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Le document en format XML
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<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>Schaller Research Group at the University of Heidelberg and the DKFZ, Heidelberg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Schaller Research Group at the University of Heidelberg and the DKFZ, Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lohmann, Volker" sort="Lohmann, Volker" uniqKey="Lohmann V" first="Volker" last="Lohmann">Volker Lohmann</name>
<affiliation wicri:level="3"><nlm:aff id="aff003"><addr-line>Department of Infectious Diseases, Molecular Virology, Heidelberg University, Im Neuenheimer Feld 345, Heidelberg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Infectious Diseases, Molecular Virology, Heidelberg University, Im Neuenheimer Feld 345, Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">PLoS Pathogens</title>
<idno type="ISSN">1553-7366</idno>
<idno type="eISSN">1553-7374</idno>
<imprint><date when="2017">2017</date>
</imprint>
</series>
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<front><div type="abstract" xml:lang="en"><p>Human noroviruses (huNoV) are the most frequent cause of non-bacterial acute gastroenteritis worldwide, particularly genogroup II genotype 4 (GII.4) variants. The viral nonstructural (NS) proteins encoded by the ORF1 polyprotein induce vesical clusters harboring the viral replication sites. Little is known so far about the ultrastructure of these replication organelles or the contribution of individual NS proteins to their biogenesis. We compared the ultrastructural changes induced by expression of norovirus ORF1 polyproteins with those induced upon infection with murine norovirus (MNV). Characteristic membrane alterations induced by ORF1 expression resembled those found in MNV infected cells, consisting of vesicle accumulations likely built from the endoplasmic reticulum (ER) which included single membrane vesicles (SMVs), double membrane vesicles (DMVs) and multi membrane vesicles (MMVs). In-depth analysis using electron tomography suggested that MMVs originate through the enwrapping of SMVs with tubular structures similar to mechanisms reported for picornaviruses. Expression of GII.4 NS1-2, NS3 and NS4 fused to GFP revealed distinct membrane alterations when analyzed by correlative light and electron microscopy. Expression of NS1-2 induced proliferation of smooth ER membranes forming long tubular structures that were affected by mutations in the active center of the putative NS1-2 hydrolase domain. NS3 was associated with ER membranes around lipid droplets (LDs) and induced the formation of convoluted membranes, which were even more pronounced in case of NS4. Interestingly, NS4 was the only GII.4 protein capable of inducing SMV and DMV formation when expressed individually. Our work provides the first ultrastructural analysis of norovirus GII.4 induced vesicle clusters and suggests that their morphology and biogenesis is most similar to picornaviruses. We further identified NS4 as a key factor in the formation of membrane alterations of huNoV and provide models of the putative membrane topologies of NS1-2, NS3 and NS4 to guide future studies.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Pires, Sm" uniqKey="Pires S">SM Pires</name>
</author>
<author><name sortKey="Fischer Walker, Cl" uniqKey="Fischer Walker C">CL Fischer-Walker</name>
</author>
<author><name sortKey="Lanata, Cf" uniqKey="Lanata C">CF Lanata</name>
</author>
<author><name sortKey="Devleesschauwer, B" uniqKey="Devleesschauwer B">B Devleesschauwer</name>
</author>
<author><name sortKey="Hall, Aj" uniqKey="Hall A">AJ Hall</name>
</author>
<author><name sortKey="Kirk, Md" uniqKey="Kirk M">MD Kirk</name>
</author>
<author><name sortKey="Duarte, As" uniqKey="Duarte A">AS Duarte</name>
</author>
<author><name sortKey="Black, Re" uniqKey="Black R">RE Black</name>
</author>
<author><name sortKey="Angulo, Fj" uniqKey="Angulo F">FJ Angulo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Donaldson, Ef" uniqKey="Donaldson E">EF Donaldson</name>
</author>
<author><name sortKey="Lindesmith, Lc" uniqKey="Lindesmith L">LC Lindesmith</name>
</author>
<author><name sortKey="Lobue, Ad" uniqKey="Lobue A">AD Lobue</name>
</author>
<author><name sortKey="Baric, Rs" uniqKey="Baric R">RS Baric</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Siebenga, Jj" uniqKey="Siebenga J">JJ Siebenga</name>
</author>
<author><name sortKey="Lemey, P" uniqKey="Lemey P">P Lemey</name>
</author>
<author><name sortKey="Kosakovsky Pond, Sl" uniqKey="Kosakovsky Pond S">SL Kosakovsky Pond</name>
</author>
<author><name sortKey="Rambaut, A" uniqKey="Rambaut A">A Rambaut</name>
</author>
<author><name sortKey="Vennema, H" uniqKey="Vennema H">H Vennema</name>
</author>
<author><name sortKey="Koopmans, M" uniqKey="Koopmans M">M Koopmans</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hoa Tran, Tn" uniqKey="Hoa Tran T">TN Hoa Tran</name>
</author>
<author><name sortKey="Trainor, E" uniqKey="Trainor E">E Trainor</name>
</author>
<author><name sortKey="Nakagomi, T" uniqKey="Nakagomi T">T Nakagomi</name>
</author>
<author><name sortKey="Cunliffe, Na" uniqKey="Cunliffe N">NA Cunliffe</name>
</author>
<author><name sortKey="Nakagomi, O" uniqKey="Nakagomi O">O Nakagomi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Eden, Js" uniqKey="Eden J">JS Eden</name>
</author>
<author><name sortKey="Hewitt, J" uniqKey="Hewitt J">J Hewitt</name>
</author>
<author><name sortKey="Lim, Kl" uniqKey="Lim K">KL Lim</name>
</author>
<author><name sortKey="Boni, Mf" uniqKey="Boni M">MF Boni</name>
</author>
<author><name sortKey="Merif, J" uniqKey="Merif J">J Merif</name>
</author>
<author><name sortKey="Greening, G" uniqKey="Greening G">G Greening</name>
</author>
<author><name sortKey="Ratcliff, Rm" uniqKey="Ratcliff R">RM Ratcliff</name>
</author>
<author><name sortKey="Holmes, Ec" uniqKey="Holmes E">EC Holmes</name>
</author>
<author><name sortKey="Tanaka, Mm" uniqKey="Tanaka M">MM Tanaka</name>
</author>
<author><name sortKey="Rawlinson, Wd" uniqKey="Rawlinson W">WD Rawlinson</name>
</author>
<author><name sortKey="White, Pa" uniqKey="White P">PA White</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Karst, Sm" uniqKey="Karst S">SM Karst</name>
</author>
<author><name sortKey="Wobus, Ce" uniqKey="Wobus C">CE Wobus</name>
</author>
<author><name sortKey="Goodfellow, Ig" uniqKey="Goodfellow I">IG Goodfellow</name>
</author>
<author><name sortKey="Green, Ky" uniqKey="Green K">KY Green</name>
</author>
<author><name sortKey="Virgin, Hw" uniqKey="Virgin H">HW Virgin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mcfadden, N" uniqKey="Mcfadden N">N McFadden</name>
</author>
<author><name sortKey="Bailey, D" uniqKey="Bailey D">D Bailey</name>
</author>
<author><name sortKey="Carrara, G" uniqKey="Carrara G">G Carrara</name>
</author>
<author><name sortKey="Benson, A" uniqKey="Benson A">A Benson</name>
</author>
<author><name sortKey="Chaudhry, Y" uniqKey="Chaudhry Y">Y Chaudhry</name>
</author>
<author><name sortKey="Shortland, A" uniqKey="Shortland A">A Shortland</name>
</author>
<author><name sortKey="Heeney, J" uniqKey="Heeney J">J Heeney</name>
</author>
<author><name sortKey="Yarovinsky, F" uniqKey="Yarovinsky F">F Yarovinsky</name>
</author>
<author><name sortKey="Simmonds, P" uniqKey="Simmonds P">P Simmonds</name>
</author>
<author><name sortKey="Macdonald, A" uniqKey="Macdonald A">A Macdonald</name>
</author>
<author><name sortKey="Goodfellow, I" uniqKey="Goodfellow I">I Goodfellow</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Thorne, Lg" uniqKey="Thorne L">LG Thorne</name>
</author>
<author><name sortKey="Goodfellow, Ig" uniqKey="Goodfellow I">IG Goodfellow</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Baker, Es" uniqKey="Baker E">ES Baker</name>
</author>
<author><name sortKey="Luckner, Sr" uniqKey="Luckner S">SR Luckner</name>
</author>
<author><name sortKey="Krause, Kl" uniqKey="Krause K">KL Krause</name>
</author>
<author><name sortKey="Lambden, Pr" uniqKey="Lambden P">PR Lambden</name>
</author>
<author><name sortKey="Clarke, In" uniqKey="Clarke I">IN Clarke</name>
</author>
<author><name sortKey="Ward, Vk" uniqKey="Ward V">VK Ward</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Anantharaman, V" uniqKey="Anantharaman V">V Anantharaman</name>
</author>
<author><name sortKey="Aravind, L" uniqKey="Aravind L">L Aravind</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fernandez Vega, V" uniqKey="Fernandez Vega V">V Fernandez-Vega</name>
</author>
<author><name sortKey="Sosnovtsev, Sv" uniqKey="Sosnovtsev S">SV Sosnovtsev</name>
</author>
<author><name sortKey="Belliot, G" uniqKey="Belliot G">G Belliot</name>
</author>
<author><name sortKey="King, Ad" uniqKey="King A">AD King</name>
</author>
<author><name sortKey="Mitra, T" uniqKey="Mitra T">T Mitra</name>
</author>
<author><name sortKey="Gorbalenya, A" uniqKey="Gorbalenya A">A Gorbalenya</name>
</author>
<author><name sortKey="Green, Ky" uniqKey="Green K">KY Green</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sosnovtsev, Sv" uniqKey="Sosnovtsev S">SV Sosnovtsev</name>
</author>
<author><name sortKey="Belliot, G" uniqKey="Belliot G">G Belliot</name>
</author>
<author><name sortKey="Chang, Ko" uniqKey="Chang K">KO Chang</name>
</author>
<author><name sortKey="Prikhodko, Vg" uniqKey="Prikhodko V">VG Prikhodko</name>
</author>
<author><name sortKey="Thackray, Lb" uniqKey="Thackray L">LB Thackray</name>
</author>
<author><name sortKey="Wobus, Ce" uniqKey="Wobus C">CE Wobus</name>
</author>
<author><name sortKey="Karst, Sm" uniqKey="Karst S">SM Karst</name>
</author>
<author><name sortKey="Virgin, Hw" uniqKey="Virgin H">HW Virgin</name>
</author>
<author><name sortKey="Green, Ky" uniqKey="Green K">KY Green</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hyde, Jl" uniqKey="Hyde J">JL Hyde</name>
</author>
<author><name sortKey="Mackenzie, Jm" uniqKey="Mackenzie J">JM Mackenzie</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pfister, T" uniqKey="Pfister T">T Pfister</name>
</author>
<author><name sortKey="Wimmer, E" uniqKey="Wimmer E">E Wimmer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hyde, Jl" uniqKey="Hyde J">JL Hyde</name>
</author>
<author><name sortKey="Sosnovtsev, Sv" uniqKey="Sosnovtsev S">SV Sosnovtsev</name>
</author>
<author><name sortKey="Green, Ky" uniqKey="Green K">KY Green</name>
</author>
<author><name sortKey="Wobus, C" uniqKey="Wobus C">C Wobus</name>
</author>
<author><name sortKey="Virgin, Hw" uniqKey="Virgin H">HW Virgin</name>
</author>
<author><name sortKey="Mackenzie, Jm" uniqKey="Mackenzie J">JM Mackenzie</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sharp, Tm" uniqKey="Sharp T">TM Sharp</name>
</author>
<author><name sortKey="Guix, S" uniqKey="Guix S">S Guix</name>
</author>
<author><name sortKey="Katayama, K" uniqKey="Katayama K">K Katayama</name>
</author>
<author><name sortKey="Crawford, Se" uniqKey="Crawford S">SE Crawford</name>
</author>
<author><name sortKey="Estes, Mk" uniqKey="Estes M">MK Estes</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hillenbrand, B" uniqKey="Hillenbrand B">B Hillenbrand</name>
</author>
<author><name sortKey="Gunzel, D" uniqKey="Gunzel D">D Gunzel</name>
</author>
<author><name sortKey="Richter, Jf" uniqKey="Richter J">JF Richter</name>
</author>
<author><name sortKey="Hohne, M" uniqKey="Hohne M">M Hohne</name>
</author>
<author><name sortKey="Schreier, E" uniqKey="Schreier E">E Schreier</name>
</author>
<author><name sortKey="Schulzke, Jd" uniqKey="Schulzke J">JD Schulzke</name>
</author>
<author><name sortKey="Mankertz, J" uniqKey="Mankertz J">J Mankertz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chaudhry, Y" uniqKey="Chaudhry Y">Y Chaudhry</name>
</author>
<author><name sortKey="Nayak, A" uniqKey="Nayak A">A Nayak</name>
</author>
<author><name sortKey="Bordeleau, Me" uniqKey="Bordeleau M">ME Bordeleau</name>
</author>
<author><name sortKey="Tanaka, J" uniqKey="Tanaka J">J Tanaka</name>
</author>
<author><name sortKey="Pelletier, J" uniqKey="Pelletier J">J Pelletier</name>
</author>
<author><name sortKey="Belsham, Gj" uniqKey="Belsham G">GJ Belsham</name>
</author>
<author><name sortKey="Roberts, Lo" uniqKey="Roberts L">LO Roberts</name>
</author>
<author><name sortKey="Goodfellow, Ig" uniqKey="Goodfellow I">IG Goodfellow</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liu, B" uniqKey="Liu B">B Liu</name>
</author>
<author><name sortKey="Clarke, In" uniqKey="Clarke I">IN Clarke</name>
</author>
<author><name sortKey="Lambden, Pr" uniqKey="Lambden P">PR Lambden</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Xi, Jn" uniqKey="Xi J">JN Xi</name>
</author>
<author><name sortKey="Graham, Dy" uniqKey="Graham D">DY Graham</name>
</author>
<author><name sortKey="Wang, Kn" uniqKey="Wang K">KN Wang</name>
</author>
<author><name sortKey="Estes, Mk" uniqKey="Estes M">MK Estes</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hardy, Me" uniqKey="Hardy M">ME Hardy</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Romero Brey, I" uniqKey="Romero Brey I">I Romero-Brey</name>
</author>
<author><name sortKey="Bartenschlager, R" uniqKey="Bartenschlager R">R Bartenschlager</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Harak, C" uniqKey="Harak C">C Harak</name>
</author>
<author><name sortKey="Lohmann, V" uniqKey="Lohmann V">V Lohmann</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kallio, K" uniqKey="Kallio K">K Kallio</name>
</author>
<author><name sortKey="Hellstrom, K" uniqKey="Hellstrom K">K Hellstrom</name>
</author>
<author><name sortKey="Balistreri, G" uniqKey="Balistreri G">G Balistreri</name>
</author>
<author><name sortKey="Spuul, P" uniqKey="Spuul P">P Spuul</name>
</author>
<author><name sortKey="Jokitalo, E" uniqKey="Jokitalo E">E Jokitalo</name>
</author>
<author><name sortKey="Ahola, T" uniqKey="Ahola T">T Ahola</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Schwartz, M" uniqKey="Schwartz M">M Schwartz</name>
</author>
<author><name sortKey="Chen, J" uniqKey="Chen J">J Chen</name>
</author>
<author><name sortKey="Janda, M" uniqKey="Janda M">M Janda</name>
</author>
<author><name sortKey="Sullivan, M" uniqKey="Sullivan M">M Sullivan</name>
</author>
<author><name sortKey="Den, Bj" uniqKey="Den B">BJ den</name>
</author>
<author><name sortKey="Ahlquist, P" uniqKey="Ahlquist P">P Ahlquist</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Suhy, Da" uniqKey="Suhy D">DA Suhy</name>
</author>
<author><name sortKey="Giddings, Th" uniqKey="Giddings T">TH Giddings</name>
</author>
<author><name sortKey="Kirkegaard, K" uniqKey="Kirkegaard K">K Kirkegaard</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Barco, A" uniqKey="Barco A">A Barco</name>
</author>
<author><name sortKey="Carrasco, L" uniqKey="Carrasco L">L Carrasco</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gosert, R" uniqKey="Gosert R">R Gosert</name>
</author>
<author><name sortKey="Egger, D" uniqKey="Egger D">D Egger</name>
</author>
<author><name sortKey="Bienz, K" uniqKey="Bienz K">K Bienz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Teterina, Nl" uniqKey="Teterina N">NL Teterina</name>
</author>
<author><name sortKey="Egger, D" uniqKey="Egger D">D Egger</name>
</author>
<author><name sortKey="Bienz, K" uniqKey="Bienz K">K Bienz</name>
</author>
<author><name sortKey="Brown, Dm" uniqKey="Brown D">DM Brown</name>
</author>
<author><name sortKey="Semler, Bl" uniqKey="Semler B">BL Semler</name>
</author>
<author><name sortKey="Ehrenfeld, E" uniqKey="Ehrenfeld E">E Ehrenfeld</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Egger, D" uniqKey="Egger D">D Egger</name>
</author>
<author><name sortKey="Wolk, B" uniqKey="Wolk B">B Wolk</name>
</author>
<author><name sortKey="Gosert, R" uniqKey="Gosert R">R Gosert</name>
</author>
<author><name sortKey="Bianchi, L" uniqKey="Bianchi L">L Bianchi</name>
</author>
<author><name sortKey="Blum, He" uniqKey="Blum H">HE Blum</name>
</author>
<author><name sortKey="Moradpour, D" uniqKey="Moradpour D">D Moradpour</name>
</author>
<author><name sortKey="Bienz, K" uniqKey="Bienz K">K Bienz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Romero Brey, I" uniqKey="Romero Brey I">I Romero-Brey</name>
</author>
<author><name sortKey="Merz, A" uniqKey="Merz A">A Merz</name>
</author>
<author><name sortKey="Chiramel, A" uniqKey="Chiramel A">A Chiramel</name>
</author>
<author><name sortKey="Lee, Jy" uniqKey="Lee J">JY Lee</name>
</author>
<author><name sortKey="Chlanda, P" uniqKey="Chlanda P">P Chlanda</name>
</author>
<author><name sortKey="Haselman, U" uniqKey="Haselman U">U Haselman</name>
</author>
<author><name sortKey="Santarella Mellwig, R" uniqKey="Santarella Mellwig R">R Santarella-Mellwig</name>
</author>
<author><name sortKey="Habermann, A" uniqKey="Habermann A">A Habermann</name>
</author>
<author><name sortKey="Hoppe, S" uniqKey="Hoppe S">S Hoppe</name>
</author>
<author><name sortKey="Kallis, S" uniqKey="Kallis S">S Kallis</name>
</author>
<author><name sortKey="Walther, P" uniqKey="Walther P">P Walther</name>
</author>
<author><name sortKey="Antony, C" uniqKey="Antony C">C Antony</name>
</author>
<author><name sortKey="Krijnse Locker, J" uniqKey="Krijnse Locker J">J Krijnse-Locker</name>
</author>
<author><name sortKey="Bartenschlager, R" uniqKey="Bartenschlager R">R Bartenschlager</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Reiss, S" uniqKey="Reiss S">S Reiss</name>
</author>
<author><name sortKey="Harak, C" uniqKey="Harak C">C Harak</name>
</author>
<author><name sortKey="Romero Brey, I" uniqKey="Romero Brey I">I Romero-Brey</name>
</author>
<author><name sortKey="Radujkovic, D" uniqKey="Radujkovic D">D Radujkovic</name>
</author>
<author><name sortKey="Klein, R" uniqKey="Klein R">R Klein</name>
</author>
<author><name sortKey="Ruggieri, A" uniqKey="Ruggieri A">A Ruggieri</name>
</author>
<author><name sortKey="Rebhan, I" uniqKey="Rebhan I">I Rebhan</name>
</author>
<author><name sortKey="Bartenschlager, R" uniqKey="Bartenschlager R">R Bartenschlager</name>
</author>
<author><name sortKey="Lohmann, V" uniqKey="Lohmann V">V Lohmann</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Romero Brey, I" uniqKey="Romero Brey I">I Romero-Brey</name>
</author>
<author><name sortKey="Berger, C" uniqKey="Berger C">C Berger</name>
</author>
<author><name sortKey="Kallis, S" uniqKey="Kallis S">S Kallis</name>
</author>
<author><name sortKey="Kolovou, A" uniqKey="Kolovou A">A Kolovou</name>
</author>
<author><name sortKey="Paul, D" uniqKey="Paul D">D Paul</name>
</author>
<author><name sortKey="Lohmann, V" uniqKey="Lohmann V">V Lohmann</name>
</author>
<author><name sortKey="Bartenschlager, R" uniqKey="Bartenschlager R">R Bartenschlager</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Teterina, Nl" uniqKey="Teterina N">NL Teterina</name>
</author>
<author><name sortKey="Bienz, K" uniqKey="Bienz K">K Bienz</name>
</author>
<author><name sortKey="Egger, D" uniqKey="Egger D">D Egger</name>
</author>
<author><name sortKey="Gorbalenya, Ae" uniqKey="Gorbalenya A">AE Gorbalenya</name>
</author>
<author><name sortKey="Ehrenfeld, E" uniqKey="Ehrenfeld E">E Ehrenfeld</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, J" uniqKey="Wang J">J Wang</name>
</author>
<author><name sortKey="Ptacek, Jb" uniqKey="Ptacek J">JB Ptacek</name>
</author>
<author><name sortKey="Kirkegaard, K" uniqKey="Kirkegaard K">K Kirkegaard</name>
</author>
<author><name sortKey="Bullitt, E" uniqKey="Bullitt E">E Bullitt</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Esser Nobis, K" uniqKey="Esser Nobis K">K Esser-Nobis</name>
</author>
<author><name sortKey="Romero Brey, I" uniqKey="Romero Brey I">I Romero-Brey</name>
</author>
<author><name sortKey="Ganten, Tm" uniqKey="Ganten T">TM Ganten</name>
</author>
<author><name sortKey="Gouttenoire, J" uniqKey="Gouttenoire J">J Gouttenoire</name>
</author>
<author><name sortKey="Harak, C" uniqKey="Harak C">C Harak</name>
</author>
<author><name sortKey="Klein, R" uniqKey="Klein R">R Klein</name>
</author>
<author><name sortKey="Schemmer, P" uniqKey="Schemmer P">P Schemmer</name>
</author>
<author><name sortKey="Binder, M" uniqKey="Binder M">M Binder</name>
</author>
<author><name sortKey="Schnitzler, P" uniqKey="Schnitzler P">P Schnitzler</name>
</author>
<author><name sortKey="Moradpour, D" uniqKey="Moradpour D">D Moradpour</name>
</author>
<author><name sortKey="Bartenschlager, R" uniqKey="Bartenschlager R">R Bartenschlager</name>
</author>
<author><name sortKey="Polyak, Sj" uniqKey="Polyak S">SJ Polyak</name>
</author>
<author><name sortKey="Stremmel, W" uniqKey="Stremmel W">W Stremmel</name>
</author>
<author><name sortKey="Penin, F" uniqKey="Penin F">F Penin</name>
</author>
<author><name sortKey="Eisenbach, C" uniqKey="Eisenbach C">C Eisenbach</name>
</author>
<author><name sortKey="Lohmann, V" uniqKey="Lohmann V">V Lohmann</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Berger, C" uniqKey="Berger C">C Berger</name>
</author>
<author><name sortKey="Romero Brey, I" uniqKey="Romero Brey I">I Romero-Brey</name>
</author>
<author><name sortKey="Radujkovic, D" uniqKey="Radujkovic D">D Radujkovic</name>
</author>
<author><name sortKey="Terreux, R" uniqKey="Terreux R">R Terreux</name>
</author>
<author><name sortKey="Zayas, M" uniqKey="Zayas M">M Zayas</name>
</author>
<author><name sortKey="Paul, D" uniqKey="Paul D">D Paul</name>
</author>
<author><name sortKey="Harak, C" uniqKey="Harak C">C Harak</name>
</author>
<author><name sortKey="Hoppe, S" uniqKey="Hoppe S">S Hoppe</name>
</author>
<author><name sortKey="Gao, M" uniqKey="Gao M">M Gao</name>
</author>
<author><name sortKey="Penin, F" uniqKey="Penin F">F Penin</name>
</author>
<author><name sortKey="Lohmann, V" uniqKey="Lohmann V">V Lohmann</name>
</author>
<author><name sortKey="Bartenschlager, R" uniqKey="Bartenschlager R">R Bartenschlager</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Madan, V" uniqKey="Madan V">V Madan</name>
</author>
<author><name sortKey="Paul, D" uniqKey="Paul D">D Paul</name>
</author>
<author><name sortKey="Lohmann, V" uniqKey="Lohmann V">V Lohmann</name>
</author>
<author><name sortKey="Bartenschlager, R" uniqKey="Bartenschlager R">R Bartenschlager</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lindesmith, Lc" uniqKey="Lindesmith L">LC Lindesmith</name>
</author>
<author><name sortKey="Donaldson, Ef" uniqKey="Donaldson E">EF Donaldson</name>
</author>
<author><name sortKey="Lobue, Ad" uniqKey="Lobue A">AD Lobue</name>
</author>
<author><name sortKey="Cannon, Jl" uniqKey="Cannon J">JL Cannon</name>
</author>
<author><name sortKey="Zheng, Dp" uniqKey="Zheng D">DP Zheng</name>
</author>
<author><name sortKey="Vinje, J" uniqKey="Vinje J">J Vinje</name>
</author>
<author><name sortKey="Baric, Rs" uniqKey="Baric R">RS Baric</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chang, Ko" uniqKey="Chang K">KO Chang</name>
</author>
<author><name sortKey="Sosnovtsev, Sv" uniqKey="Sosnovtsev S">SV Sosnovtsev</name>
</author>
<author><name sortKey="Belliot, G" uniqKey="Belliot G">G Belliot</name>
</author>
<author><name sortKey="King, Ad" uniqKey="King A">AD King</name>
</author>
<author><name sortKey="Green, Ky" uniqKey="Green K">KY Green</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Katayama, K" uniqKey="Katayama K">K Katayama</name>
</author>
<author><name sortKey="Murakami, K" uniqKey="Murakami K">K Murakami</name>
</author>
<author><name sortKey="Sharp, Tm" uniqKey="Sharp T">TM Sharp</name>
</author>
<author><name sortKey="Guix, S" uniqKey="Guix S">S Guix</name>
</author>
<author><name sortKey="Oka, T" uniqKey="Oka T">T Oka</name>
</author>
<author><name sortKey="Takai Todaka, R" uniqKey="Takai Todaka R">R Takai-Todaka</name>
</author>
<author><name sortKey="Nakanishi, A" uniqKey="Nakanishi A">A Nakanishi</name>
</author>
<author><name sortKey="Crawford, Se" uniqKey="Crawford S">SE Crawford</name>
</author>
<author><name sortKey="Atmar, Rl" uniqKey="Atmar R">RL Atmar</name>
</author>
<author><name sortKey="Estes, Mk" uniqKey="Estes M">MK Estes</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jones, Mk" uniqKey="Jones M">MK Jones</name>
</author>
<author><name sortKey="Watanabe, M" uniqKey="Watanabe M">M Watanabe</name>
</author>
<author><name sortKey="Zhu, S" uniqKey="Zhu S">S Zhu</name>
</author>
<author><name sortKey="Graves, Cl" uniqKey="Graves C">CL Graves</name>
</author>
<author><name sortKey="Keyes, Lr" uniqKey="Keyes L">LR Keyes</name>
</author>
<author><name sortKey="Grau, Kr" uniqKey="Grau K">KR Grau</name>
</author>
<author><name sortKey="Gonzalez Hernandez, Mb" uniqKey="Gonzalez Hernandez M">MB Gonzalez-Hernandez</name>
</author>
<author><name sortKey="Iovine, Nm" uniqKey="Iovine N">NM Iovine</name>
</author>
<author><name sortKey="Wobus, Ce" uniqKey="Wobus C">CE Wobus</name>
</author>
<author><name sortKey="Vinje, J" uniqKey="Vinje J">J Vinje</name>
</author>
<author><name sortKey="Tibbetts, Sa" uniqKey="Tibbetts S">SA Tibbetts</name>
</author>
<author><name sortKey="Wallet, Sm" uniqKey="Wallet S">SM Wallet</name>
</author>
<author><name sortKey="Karst, Sm" uniqKey="Karst S">SM Karst</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ettayebi, K" uniqKey="Ettayebi K">K Ettayebi</name>
</author>
<author><name sortKey="Crawford, Se" uniqKey="Crawford S">SE Crawford</name>
</author>
<author><name sortKey="Murakami, K" uniqKey="Murakami K">K Murakami</name>
</author>
<author><name sortKey="Broughman, Jr" uniqKey="Broughman J">JR Broughman</name>
</author>
<author><name sortKey="Karandikar, U" uniqKey="Karandikar U">U Karandikar</name>
</author>
<author><name sortKey="Tenge, Vr" uniqKey="Tenge V">VR Tenge</name>
</author>
<author><name sortKey="Neill, Fh" uniqKey="Neill F">FH Neill</name>
</author>
<author><name sortKey="Blutt, Se" uniqKey="Blutt S">SE Blutt</name>
</author>
<author><name sortKey="Zeng, Xl" uniqKey="Zeng X">XL Zeng</name>
</author>
<author><name sortKey="Qu, L" uniqKey="Qu L">L Qu</name>
</author>
<author><name sortKey="Kou, B" uniqKey="Kou B">B Kou</name>
</author>
<author><name sortKey="Opekun, Ar" uniqKey="Opekun A">AR Opekun</name>
</author>
<author><name sortKey="Burrin, D" uniqKey="Burrin D">D Burrin</name>
</author>
<author><name sortKey="Graham, Dy" uniqKey="Graham D">DY Graham</name>
</author>
<author><name sortKey="Ramani, S" uniqKey="Ramani S">S Ramani</name>
</author>
<author><name sortKey="Atmar, Rl" uniqKey="Atmar R">RL Atmar</name>
</author>
<author><name sortKey="Estes, Mk" uniqKey="Estes M">MK Estes</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wobus, Ce" uniqKey="Wobus C">CE Wobus</name>
</author>
<author><name sortKey="Karst, Sm" uniqKey="Karst S">SM Karst</name>
</author>
<author><name sortKey="Thackray, Lb" uniqKey="Thackray L">LB Thackray</name>
</author>
<author><name sortKey="Chang, Ko" uniqKey="Chang K">KO Chang</name>
</author>
<author><name sortKey="Sosnovtsev, Sv" uniqKey="Sosnovtsev S">SV Sosnovtsev</name>
</author>
<author><name sortKey="Belliot, G" uniqKey="Belliot G">G Belliot</name>
</author>
<author><name sortKey="Krug, A" uniqKey="Krug A">A Krug</name>
</author>
<author><name sortKey="Mackenzie, Jm" uniqKey="Mackenzie J">JM Mackenzie</name>
</author>
<author><name sortKey="Green, Ky" uniqKey="Green K">KY Green</name>
</author>
<author><name sortKey="Virgin, Hw" uniqKey="Virgin H">HW Virgin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hyde, Jl" uniqKey="Hyde J">JL Hyde</name>
</author>
<author><name sortKey="Gillespie, Lk" uniqKey="Gillespie L">LK Gillespie</name>
</author>
<author><name sortKey="Mackenzie, Jm" uniqKey="Mackenzie J">JM Mackenzie</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cotton, Bt" uniqKey="Cotton B">BT Cotton</name>
</author>
<author><name sortKey="Hyde, Jl" uniqKey="Hyde J">JL Hyde</name>
</author>
<author><name sortKey="Sarvestani, St" uniqKey="Sarvestani S">ST Sarvestani</name>
</author>
<author><name sortKey="Sosnovtsev, Sv" uniqKey="Sosnovtsev S">SV Sosnovtsev</name>
</author>
<author><name sortKey="Green, Ky" uniqKey="Green K">KY Green</name>
</author>
<author><name sortKey="White, Pa" uniqKey="White P">PA White</name>
</author>
<author><name sortKey="Mackenzie, Jm" uniqKey="Mackenzie J">JM Mackenzie</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Orchard, Rc" uniqKey="Orchard R">RC Orchard</name>
</author>
<author><name sortKey="Wilen, Cb" uniqKey="Wilen C">CB Wilen</name>
</author>
<author><name sortKey="Doench, Jg" uniqKey="Doench J">JG Doench</name>
</author>
<author><name sortKey="Baldridge, Mt" uniqKey="Baldridge M">MT Baldridge</name>
</author>
<author><name sortKey="Mccune, Bt" uniqKey="Mccune B">BT McCune</name>
</author>
<author><name sortKey="Lee, Yc" uniqKey="Lee Y">YC Lee</name>
</author>
<author><name sortKey="Lee, S" uniqKey="Lee S">S Lee</name>
</author>
<author><name sortKey="Pruett Miller, Sm" uniqKey="Pruett Miller S">SM Pruett-Miller</name>
</author>
<author><name sortKey="Nelson, Ca" uniqKey="Nelson C">CA Nelson</name>
</author>
<author><name sortKey="Fremont, Dh" uniqKey="Fremont D">DH Fremont</name>
</author>
<author><name sortKey="Virgin, Hw" uniqKey="Virgin H">HW Virgin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Haga, K" uniqKey="Haga K">K Haga</name>
</author>
<author><name sortKey="Fujimoto, A" uniqKey="Fujimoto A">A Fujimoto</name>
</author>
<author><name sortKey="Takai Todaka, R" uniqKey="Takai Todaka R">R Takai-Todaka</name>
</author>
<author><name sortKey="Miki, M" uniqKey="Miki M">M Miki</name>
</author>
<author><name sortKey="Doan, Yh" uniqKey="Doan Y">YH Doan</name>
</author>
<author><name sortKey="Murakami, K" uniqKey="Murakami K">K Murakami</name>
</author>
<author><name sortKey="Yokoyama, M" uniqKey="Yokoyama M">M Yokoyama</name>
</author>
<author><name sortKey="Murata, K" uniqKey="Murata K">K Murata</name>
</author>
<author><name sortKey="Nakanishi, A" uniqKey="Nakanishi A">A Nakanishi</name>
</author>
<author><name sortKey="Katayama, K" uniqKey="Katayama K">K Katayama</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tu, Et" uniqKey="Tu E">ET Tu</name>
</author>
<author><name sortKey="Bull, Ra" uniqKey="Bull R">RA Bull</name>
</author>
<author><name sortKey="Greening, Ge" uniqKey="Greening G">GE Greening</name>
</author>
<author><name sortKey="Hewitt, J" uniqKey="Hewitt J">J Hewitt</name>
</author>
<author><name sortKey="Lyon, Mj" uniqKey="Lyon M">MJ Lyon</name>
</author>
<author><name sortKey="Marshall, Ja" uniqKey="Marshall J">JA Marshall</name>
</author>
<author><name sortKey="Mciver, Cj" uniqKey="Mciver C">CJ McIver</name>
</author>
<author><name sortKey="Rawlinson, Wd" uniqKey="Rawlinson W">WD Rawlinson</name>
</author>
<author><name sortKey="White, Pa" uniqKey="White P">PA White</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yen, C" uniqKey="Yen C">C Yen</name>
</author>
<author><name sortKey="Wikswo, Me" uniqKey="Wikswo M">ME Wikswo</name>
</author>
<author><name sortKey="Lopman, Ba" uniqKey="Lopman B">BA Lopman</name>
</author>
<author><name sortKey="Vinje, J" uniqKey="Vinje J">J Vinje</name>
</author>
<author><name sortKey="Parashar, Ud" uniqKey="Parashar U">UD Parashar</name>
</author>
<author><name sortKey="Hall, Aj" uniqKey="Hall A">AJ Hall</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Eden, Js" uniqKey="Eden J">JS Eden</name>
</author>
<author><name sortKey="Tanaka, Mm" uniqKey="Tanaka M">MM Tanaka</name>
</author>
<author><name sortKey="Boni, Mf" uniqKey="Boni M">MF Boni</name>
</author>
<author><name sortKey="Rawlinson, Wd" uniqKey="Rawlinson W">WD Rawlinson</name>
</author>
<author><name sortKey="White, Pa" uniqKey="White P">PA White</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Belliot, G" uniqKey="Belliot G">G Belliot</name>
</author>
<author><name sortKey="Sosnovtsev, Sv" uniqKey="Sosnovtsev S">SV Sosnovtsev</name>
</author>
<author><name sortKey="Mitra, T" uniqKey="Mitra T">T Mitra</name>
</author>
<author><name sortKey="Hammer, C" uniqKey="Hammer C">C Hammer</name>
</author>
<author><name sortKey="Garfield, M" uniqKey="Garfield M">M Garfield</name>
</author>
<author><name sortKey="Green, Ky" uniqKey="Green K">KY Green</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Schlegel, A" uniqKey="Schlegel A">A Schlegel</name>
</author>
<author><name sortKey="Giddings, Th" uniqKey="Giddings T">TH Giddings</name>
</author>
<author><name sortKey="Ladinsky, Ms" uniqKey="Ladinsky M">MS Ladinsky</name>
</author>
<author><name sortKey="Kirkegaard, K" uniqKey="Kirkegaard K">K Kirkegaard</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dales, S" uniqKey="Dales S">S DALES</name>
</author>
<author><name sortKey="Eggers, Hj" uniqKey="Eggers H">HJ EGGERS</name>
</author>
<author><name sortKey="Tamm, I" uniqKey="Tamm I">I TAMM</name>
</author>
<author><name sortKey="Palade, Ge" uniqKey="Palade G">GE PALADE</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Belov, Ga" uniqKey="Belov G">GA Belov</name>
</author>
<author><name sortKey="Nair, V" uniqKey="Nair V">V Nair</name>
</author>
<author><name sortKey="Hansen, Bt" uniqKey="Hansen B">BT Hansen</name>
</author>
<author><name sortKey="Hoyt, Fh" uniqKey="Hoyt F">FH Hoyt</name>
</author>
<author><name sortKey="Fischer, Er" uniqKey="Fischer E">ER Fischer</name>
</author>
<author><name sortKey="Ehrenfeld, E" uniqKey="Ehrenfeld E">E Ehrenfeld</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Limpens, Rw" uniqKey="Limpens R">RW Limpens</name>
</author>
<author><name sortKey="Van Der Schaar, Hm" uniqKey="Van Der Schaar H">HM van der Schaar</name>
</author>
<author><name sortKey="Kumar, D" uniqKey="Kumar D">D Kumar</name>
</author>
<author><name sortKey="Koster, Aj" uniqKey="Koster A">AJ Koster</name>
</author>
<author><name sortKey="Snijder, Ej" uniqKey="Snijder E">EJ Snijder</name>
</author>
<author><name sortKey="Van Kuppeveld, Fj" uniqKey="Van Kuppeveld F">FJ van Kuppeveld</name>
</author>
<author><name sortKey="Barcena, M" uniqKey="Barcena M">M Barcena</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Klopfenstein, Dr" uniqKey="Klopfenstein D">DR Klopfenstein</name>
</author>
<author><name sortKey="Kappeler, F" uniqKey="Kappeler F">F Kappeler</name>
</author>
<author><name sortKey="Hauri, Hp" uniqKey="Hauri H">HP Hauri</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Borgese, N" uniqKey="Borgese N">N Borgese</name>
</author>
<author><name sortKey="Francolini, M" uniqKey="Francolini M">M Francolini</name>
</author>
<author><name sortKey="Snapp, E" uniqKey="Snapp E">E Snapp</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Deng, Y" uniqKey="Deng Y">Y Deng</name>
</author>
<author><name sortKey="Almsherqi, Za" uniqKey="Almsherqi Z">ZA Almsherqi</name>
</author>
<author><name sortKey="Ng, Mm" uniqKey="Ng M">MM Ng</name>
</author>
<author><name sortKey="Kohlwein, Sd" uniqKey="Kohlwein S">SD Kohlwein</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chin, Dj" uniqKey="Chin D">DJ Chin</name>
</author>
<author><name sortKey="Luskey, Kl" uniqKey="Luskey K">KL Luskey</name>
</author>
<author><name sortKey="Anderson, Rg" uniqKey="Anderson R">RG Anderson</name>
</author>
<author><name sortKey="Faust, Jr" uniqKey="Faust J">JR Faust</name>
</author>
<author><name sortKey="Goldstein, Jl" uniqKey="Goldstein J">JL Goldstein</name>
</author>
<author><name sortKey="Brown, Ms" uniqKey="Brown M">MS Brown</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Golczak, M" uniqKey="Golczak M">M Golczak</name>
</author>
<author><name sortKey="Kiser, Pd" uniqKey="Kiser P">PD Kiser</name>
</author>
<author><name sortKey="Sears, Ae" uniqKey="Sears A">AE Sears</name>
</author>
<author><name sortKey="Lodowski, Dt" uniqKey="Lodowski D">DT Lodowski</name>
</author>
<author><name sortKey="Blaner, Ws" uniqKey="Blaner W">WS Blaner</name>
</author>
<author><name sortKey="Palczewski, K" uniqKey="Palczewski K">K Palczewski</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Lateef, Z" uniqKey="Lateef Z">Z Lateef</name>
</author>
<author><name sortKey="Gimenez, G" uniqKey="Gimenez G">G Gimenez</name>
</author>
<author><name sortKey="Baker, Es" uniqKey="Baker E">ES Baker</name>
</author>
<author><name sortKey="Ward, Vk" uniqKey="Ward V">VK Ward</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mccune, Bt" uniqKey="Mccune B">BT McCune</name>
</author>
<author><name sortKey="Tang, W" uniqKey="Tang W">W Tang</name>
</author>
<author><name sortKey="Lu, J" uniqKey="Lu J">J Lu</name>
</author>
<author><name sortKey="Eaglesham, Jb" uniqKey="Eaglesham J">JB Eaglesham</name>
</author>
<author><name sortKey="Thorne, L" uniqKey="Thorne L">L Thorne</name>
</author>
<author><name sortKey="Mayer, Ae" uniqKey="Mayer A">AE Mayer</name>
</author>
<author><name sortKey="Condiff, E" uniqKey="Condiff E">E Condiff</name>
</author>
<author><name sortKey="Nice, Tj" uniqKey="Nice T">TJ Nice</name>
</author>
<author><name sortKey="Goodfellow, I" uniqKey="Goodfellow I">I Goodfellow</name>
</author>
<author><name sortKey="Krezel, Am" uniqKey="Krezel A">AM Krezel</name>
</author>
<author><name sortKey="Virgin, Hw" uniqKey="Virgin H">HW Virgin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ettayebi, K" uniqKey="Ettayebi K">K Ettayebi</name>
</author>
<author><name sortKey="Hardy, Me" uniqKey="Hardy M">ME Hardy</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Snapp, El" uniqKey="Snapp E">EL Snapp</name>
</author>
<author><name sortKey="Hegde, Rs" uniqKey="Hegde R">RS Hegde</name>
</author>
<author><name sortKey="Francolini, M" uniqKey="Francolini M">M Francolini</name>
</author>
<author><name sortKey="Lombardo, F" uniqKey="Lombardo F">F Lombardo</name>
</author>
<author><name sortKey="Colombo, S" uniqKey="Colombo S">S Colombo</name>
</author>
<author><name sortKey="Pedrazzini, E" uniqKey="Pedrazzini E">E Pedrazzini</name>
</author>
<author><name sortKey="Borgese, N" uniqKey="Borgese N">N Borgese</name>
</author>
<author><name sortKey="Lippincott Schwartz, J" uniqKey="Lippincott Schwartz J">J Lippincott-Schwartz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gorbalenya, Ae" uniqKey="Gorbalenya A">AE Gorbalenya</name>
</author>
<author><name sortKey="Koonin, Ev" uniqKey="Koonin E">EV Koonin</name>
</author>
<author><name sortKey="Wolf, Yi" uniqKey="Wolf Y">YI Wolf</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Xia, H" uniqKey="Xia H">H Xia</name>
</author>
<author><name sortKey="Wang, P" uniqKey="Wang P">P Wang</name>
</author>
<author><name sortKey="Wang, Gc" uniqKey="Wang G">GC Wang</name>
</author>
<author><name sortKey="Yang, J" uniqKey="Yang J">J Yang</name>
</author>
<author><name sortKey="Sun, X" uniqKey="Sun X">X Sun</name>
</author>
<author><name sortKey="Wu, W" uniqKey="Wu W">W Wu</name>
</author>
<author><name sortKey="Qiu, Y" uniqKey="Qiu Y">Y Qiu</name>
</author>
<author><name sortKey="Shu, T" uniqKey="Shu T">T Shu</name>
</author>
<author><name sortKey="Zhao, X" uniqKey="Zhao X">X Zhao</name>
</author>
<author><name sortKey="Yin, L" uniqKey="Yin L">L Yin</name>
</author>
<author><name sortKey="Qin, Cf" uniqKey="Qin C">CF Qin</name>
</author>
<author><name sortKey="Hu, Y" uniqKey="Hu Y">Y Hu</name>
</author>
<author><name sortKey="Zhou, X" uniqKey="Zhou X">X Zhou</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Teterina, Nl" uniqKey="Teterina N">NL Teterina</name>
</author>
<author><name sortKey="Gorbalenya, Ae" uniqKey="Gorbalenya A">AE Gorbalenya</name>
</author>
<author><name sortKey="Egger, D" uniqKey="Egger D">D Egger</name>
</author>
<author><name sortKey="Bienz, K" uniqKey="Bienz K">K Bienz</name>
</author>
<author><name sortKey="Ehrenfeld, E" uniqKey="Ehrenfeld E">E Ehrenfeld</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tellinghuisen, Tl" uniqKey="Tellinghuisen T">TL Tellinghuisen</name>
</author>
<author><name sortKey="Marcotrigiano, J" uniqKey="Marcotrigiano J">J Marcotrigiano</name>
</author>
<author><name sortKey="Rice, Cm" uniqKey="Rice C">CM Rice</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Strauss, Dm" uniqKey="Strauss D">DM Strauss</name>
</author>
<author><name sortKey="Glustrom, Lw" uniqKey="Glustrom L">LW Glustrom</name>
</author>
<author><name sortKey="Wuttke, Ds" uniqKey="Wuttke D">DS Wuttke</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Teterina, Nl" uniqKey="Teterina N">NL Teterina</name>
</author>
<author><name sortKey="Pinto, Y" uniqKey="Pinto Y">Y Pinto</name>
</author>
<author><name sortKey="Weaver, Jd" uniqKey="Weaver J">JD Weaver</name>
</author>
<author><name sortKey="Jensen, Ks" uniqKey="Jensen K">KS Jensen</name>
</author>
<author><name sortKey="Ehrenfeld, E" uniqKey="Ehrenfeld E">E Ehrenfeld</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hanoulle, X" uniqKey="Hanoulle X">X Hanoulle</name>
</author>
<author><name sortKey="Badillo, A" uniqKey="Badillo A">A Badillo</name>
</author>
<author><name sortKey="Verdegem, D" uniqKey="Verdegem D">D Verdegem</name>
</author>
<author><name sortKey="Penin, F" uniqKey="Penin F">F Penin</name>
</author>
<author><name sortKey="Lippens, G" uniqKey="Lippens G">G Lippens</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hanoulle, X" uniqKey="Hanoulle X">X Hanoulle</name>
</author>
<author><name sortKey="Verdegem, D" uniqKey="Verdegem D">D Verdegem</name>
</author>
<author><name sortKey="Badillo, A" uniqKey="Badillo A">A Badillo</name>
</author>
<author><name sortKey="Wieruszeski, Jm" uniqKey="Wieruszeski J">JM Wieruszeski</name>
</author>
<author><name sortKey="Penin, F" uniqKey="Penin F">F Penin</name>
</author>
<author><name sortKey="Lippens, G" uniqKey="Lippens G">G Lippens</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Harak, C" uniqKey="Harak C">C Harak</name>
</author>
<author><name sortKey="Meyrath, M" uniqKey="Meyrath M">M Meyrath</name>
</author>
<author><name sortKey="Romero Brey, I" uniqKey="Romero Brey I">I Romero-Brey</name>
</author>
<author><name sortKey="Schenk, C" uniqKey="Schenk C">C Schenk</name>
</author>
<author><name sortKey="Gondeau, C" uniqKey="Gondeau C">C Gondeau</name>
</author>
<author><name sortKey="Schult, P" uniqKey="Schult P">P Schult</name>
</author>
<author><name sortKey="Esser Nobis, K" uniqKey="Esser Nobis K">K Esser-Nobis</name>
</author>
<author><name sortKey="Saeed, M" uniqKey="Saeed M">M Saeed</name>
</author>
<author><name sortKey="Neddermann, P" uniqKey="Neddermann P">P Neddermann</name>
</author>
<author><name sortKey="Schnitzler, P" uniqKey="Schnitzler P">P Schnitzler</name>
</author>
<author><name sortKey="Gotthardt, D" uniqKey="Gotthardt D">D Gotthardt</name>
</author>
<author><name sortKey="Perez Del Pulgar, S" uniqKey="Perez Del Pulgar S">S Perez-Del-Pulgar</name>
</author>
<author><name sortKey="Neumann Haefelin, C" uniqKey="Neumann Haefelin C">C Neumann-Haefelin</name>
</author>
<author><name sortKey="Thimme, R" uniqKey="Thimme R">R Thimme</name>
</author>
<author><name sortKey="Meuleman, P" uniqKey="Meuleman P">P Meuleman</name>
</author>
<author><name sortKey="Vondran, Fw" uniqKey="Vondran F">FW Vondran</name>
</author>
<author><name sortKey="Francesco, R" uniqKey="Francesco R">R Francesco</name>
</author>
<author><name sortKey="Rice, Cm" uniqKey="Rice C">CM Rice</name>
</author>
<author><name sortKey="Bartenschlager, R" uniqKey="Bartenschlager R">R Bartenschlager</name>
</author>
<author><name sortKey="Lohmann, V" uniqKey="Lohmann V">V Lohmann</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Reiss, S" uniqKey="Reiss S">S Reiss</name>
</author>
<author><name sortKey="Rebhan, I" uniqKey="Rebhan I">I Rebhan</name>
</author>
<author><name sortKey="Backes, P" uniqKey="Backes P">P Backes</name>
</author>
<author><name sortKey="Romero Brey, I" uniqKey="Romero Brey I">I Romero-Brey</name>
</author>
<author><name sortKey="Erfle, H" uniqKey="Erfle H">H Erfle</name>
</author>
<author><name sortKey="Matula, P" uniqKey="Matula P">P Matula</name>
</author>
<author><name sortKey="Kaderali, L" uniqKey="Kaderali L">L Kaderali</name>
</author>
<author><name sortKey="Poenisch, M" uniqKey="Poenisch M">M Poenisch</name>
</author>
<author><name sortKey="Blankenburg, H" uniqKey="Blankenburg H">H Blankenburg</name>
</author>
<author><name sortKey="Hiet, Ms" uniqKey="Hiet M">MS Hiet</name>
</author>
<author><name sortKey="Longerich, T" uniqKey="Longerich T">T Longerich</name>
</author>
<author><name sortKey="Diehl, S" uniqKey="Diehl S">S Diehl</name>
</author>
<author><name sortKey="Ramirez, F" uniqKey="Ramirez F">F Ramirez</name>
</author>
<author><name sortKey="Balla, T" uniqKey="Balla T">T Balla</name>
</author>
<author><name sortKey="Rohr, K" uniqKey="Rohr K">K Rohr</name>
</author>
<author><name sortKey="Kaul, A" uniqKey="Kaul A">A Kaul</name>
</author>
<author><name sortKey="Buhler, S" uniqKey="Buhler S">S Buhler</name>
</author>
<author><name sortKey="Pepperkok, R" uniqKey="Pepperkok R">R Pepperkok</name>
</author>
<author><name sortKey="Lengauer, T" uniqKey="Lengauer T">T Lengauer</name>
</author>
<author><name sortKey="Albrecht, M" uniqKey="Albrecht M">M Albrecht</name>
</author>
<author><name sortKey="Eils, R" uniqKey="Eils R">R Eils</name>
</author>
<author><name sortKey="Schirmacher, P" uniqKey="Schirmacher P">P Schirmacher</name>
</author>
<author><name sortKey="Lohmann, V" uniqKey="Lohmann V">V Lohmann</name>
</author>
<author><name sortKey="Bartenschlager, R" uniqKey="Bartenschlager R">R Bartenschlager</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ward, Vk" uniqKey="Ward V">VK Ward</name>
</author>
<author><name sortKey="Mccormick, Cj" uniqKey="Mccormick C">CJ McCormick</name>
</author>
<author><name sortKey="Clarke, In" uniqKey="Clarke I">IN Clarke</name>
</author>
<author><name sortKey="Salim, O" uniqKey="Salim O">O Salim</name>
</author>
<author><name sortKey="Wobus, Ce" uniqKey="Wobus C">CE Wobus</name>
</author>
<author><name sortKey="Thackray, Lb" uniqKey="Thackray L">LB Thackray</name>
</author>
<author><name sortKey="Virgin, Hw" uniqKey="Virgin H">HW Virgin</name>
</author>
<author><name sortKey="Lambden, Pr" uniqKey="Lambden P">PR Lambden</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Spearman, C" uniqKey="Spearman C">C Spearman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="K Rber, G" uniqKey="K Rber G">G Kärber</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Taube, S" uniqKey="Taube S">S Taube</name>
</author>
<author><name sortKey="Kolawole, Ao" uniqKey="Kolawole A">AO Kolawole</name>
</author>
<author><name sortKey="Hohne, M" uniqKey="Hohne M">M Hohne</name>
</author>
<author><name sortKey="Wilkinson, Je" uniqKey="Wilkinson J">JE Wilkinson</name>
</author>
<author><name sortKey="Handley, Sa" uniqKey="Handley S">SA Handley</name>
</author>
<author><name sortKey="Perry, Jw" uniqKey="Perry J">JW Perry</name>
</author>
<author><name sortKey="Thackray, Lb" uniqKey="Thackray L">LB Thackray</name>
</author>
<author><name sortKey="Akkina, R" uniqKey="Akkina R">R Akkina</name>
</author>
<author><name sortKey="Wobus, Ce" uniqKey="Wobus C">CE Wobus</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Humoud, Mn" uniqKey="Humoud M">MN Humoud</name>
</author>
<author><name sortKey="Doyle, N" uniqKey="Doyle N">N Doyle</name>
</author>
<author><name sortKey="Royall, E" uniqKey="Royall E">E Royall</name>
</author>
<author><name sortKey="Willcocks, Mm" uniqKey="Willcocks M">MM Willcocks</name>
</author>
<author><name sortKey="Sorgeloos, F" uniqKey="Sorgeloos F">F Sorgeloos</name>
</author>
<author><name sortKey="Van, Kf" uniqKey="Van K">KF van</name>
</author>
<author><name sortKey="Roberts, Lo" uniqKey="Roberts L">LO Roberts</name>
</author>
<author><name sortKey="Goodfellow, Ig" uniqKey="Goodfellow I">IG Goodfellow</name>
</author>
<author><name sortKey="Langereis, Ma" uniqKey="Langereis M">MA Langereis</name>
</author>
<author><name sortKey="Locker, N" uniqKey="Locker N">N Locker</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Schindelin, J" uniqKey="Schindelin J">J Schindelin</name>
</author>
<author><name sortKey="Arganda Carreras, I" uniqKey="Arganda Carreras I">I Arganda-Carreras</name>
</author>
<author><name sortKey="Frise, E" uniqKey="Frise E">E Frise</name>
</author>
<author><name sortKey="Kaynig, V" uniqKey="Kaynig V">V Kaynig</name>
</author>
<author><name sortKey="Longair, M" uniqKey="Longair M">M Longair</name>
</author>
<author><name sortKey="Pietzsch, T" uniqKey="Pietzsch T">T Pietzsch</name>
</author>
<author><name sortKey="Preibisch, S" uniqKey="Preibisch S">S Preibisch</name>
</author>
<author><name sortKey="Rueden, C" uniqKey="Rueden C">C Rueden</name>
</author>
<author><name sortKey="Saalfeld, S" uniqKey="Saalfeld S">S Saalfeld</name>
</author>
<author><name sortKey="Schmid, B" uniqKey="Schmid B">B Schmid</name>
</author>
<author><name sortKey="Tinevez, Jy" uniqKey="Tinevez J">JY Tinevez</name>
</author>
<author><name sortKey="White, Dj" uniqKey="White D">DJ White</name>
</author>
<author><name sortKey="Hartenstein, V" uniqKey="Hartenstein V">V Hartenstein</name>
</author>
<author><name sortKey="Eliceiri, K" uniqKey="Eliceiri K">K Eliceiri</name>
</author>
<author><name sortKey="Tomancak, P" uniqKey="Tomancak P">P Tomancak</name>
</author>
<author><name sortKey="Cardona, A" uniqKey="Cardona A">A Cardona</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hwang, S" uniqKey="Hwang S">S Hwang</name>
</author>
<author><name sortKey="Alhatlani, B" uniqKey="Alhatlani B">B Alhatlani</name>
</author>
<author><name sortKey="Arias, A" uniqKey="Arias A">A Arias</name>
</author>
<author><name sortKey="Caddy, Sl" uniqKey="Caddy S">SL Caddy</name>
</author>
<author><name sortKey="Christodoulou, C" uniqKey="Christodoulou C">C Christodoulou</name>
</author>
<author><name sortKey="Cunha, Jb" uniqKey="Cunha J">JB Cunha</name>
</author>
<author><name sortKey="Emmott, E" uniqKey="Emmott E">E Emmott</name>
</author>
<author><name sortKey="Gonzalez Hernandez, M" uniqKey="Gonzalez Hernandez M">M Gonzalez-Hernandez</name>
</author>
<author><name sortKey="Kolawole, A" uniqKey="Kolawole A">A Kolawole</name>
</author>
<author><name sortKey="Lu, J" uniqKey="Lu J">J Lu</name>
</author>
<author><name sortKey="Rippinger, C" uniqKey="Rippinger C">C Rippinger</name>
</author>
<author><name sortKey="Sorgeloos, F" uniqKey="Sorgeloos F">F Sorgeloos</name>
</author>
<author><name sortKey="Thorne, L" uniqKey="Thorne L">L Thorne</name>
</author>
<author><name sortKey="Vashist, S" uniqKey="Vashist S">S Vashist</name>
</author>
<author><name sortKey="Goodfellow, I" uniqKey="Goodfellow I">I Goodfellow</name>
</author>
<author><name sortKey="Wobus, Ce" uniqKey="Wobus C">CE Wobus</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Walther, P" uniqKey="Walther P">P Walther</name>
</author>
<author><name sortKey="Ziegler, A" uniqKey="Ziegler A">A Ziegler</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kremer, Jr" uniqKey="Kremer J">JR Kremer</name>
</author>
<author><name sortKey="Mastronarde, Dn" uniqKey="Mastronarde D">DN Mastronarde</name>
</author>
<author><name sortKey="Mcintosh, Jr" uniqKey="Mcintosh J">JR McIntosh</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Grunvogel, O" uniqKey="Grunvogel O">O Grunvogel</name>
</author>
<author><name sortKey="Esser Nobis, K" uniqKey="Esser Nobis K">K Esser-Nobis</name>
</author>
<author><name sortKey="Reustle, A" uniqKey="Reustle A">A Reustle</name>
</author>
<author><name sortKey="Schult, P" uniqKey="Schult P">P Schult</name>
</author>
<author><name sortKey="Muller, B" uniqKey="Muller B">B Muller</name>
</author>
<author><name sortKey="Metz, P" uniqKey="Metz P">P Metz</name>
</author>
<author><name sortKey="Trippler, M" uniqKey="Trippler M">M Trippler</name>
</author>
<author><name sortKey="Windisch, Mp" uniqKey="Windisch M">MP Windisch</name>
</author>
<author><name sortKey="Frese, M" uniqKey="Frese M">M Frese</name>
</author>
<author><name sortKey="Binder, M" uniqKey="Binder M">M Binder</name>
</author>
<author><name sortKey="Fackler, O" uniqKey="Fackler O">O Fackler</name>
</author>
<author><name sortKey="Bartenschlager, R" uniqKey="Bartenschlager R">R Bartenschlager</name>
</author>
<author><name sortKey="Ruggieri, A" uniqKey="Ruggieri A">A Ruggieri</name>
</author>
<author><name sortKey="Lohmann, V" uniqKey="Lohmann V">V Lohmann</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Alva, V" uniqKey="Alva V">V Alva</name>
</author>
<author><name sortKey="Nam, Sz" uniqKey="Nam S">SZ Nam</name>
</author>
<author><name sortKey="Soding, J" uniqKey="Soding J">J Soding</name>
</author>
<author><name sortKey="Lupas, An" uniqKey="Lupas A">AN Lupas</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kall, L" uniqKey="Kall L">L Kall</name>
</author>
<author><name sortKey="Krogh, A" uniqKey="Krogh A">A Krogh</name>
</author>
<author><name sortKey="Sonnhammer, El" uniqKey="Sonnhammer E">EL Sonnhammer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kall, L" uniqKey="Kall L">L Kall</name>
</author>
<author><name sortKey="Krogh, A" uniqKey="Krogh A">A Krogh</name>
</author>
<author><name sortKey="Sonnhammer, El" uniqKey="Sonnhammer E">EL Sonnhammer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Biasini, M" uniqKey="Biasini M">M Biasini</name>
</author>
<author><name sortKey="Bienert, S" uniqKey="Bienert S">S Bienert</name>
</author>
<author><name sortKey="Waterhouse, A" uniqKey="Waterhouse A">A Waterhouse</name>
</author>
<author><name sortKey="Arnold, K" uniqKey="Arnold K">K Arnold</name>
</author>
<author><name sortKey="Studer, G" uniqKey="Studer G">G Studer</name>
</author>
<author><name sortKey="Schmidt, T" uniqKey="Schmidt T">T Schmidt</name>
</author>
<author><name sortKey="Kiefer, F" uniqKey="Kiefer F">F Kiefer</name>
</author>
<author><name sortKey="Gallo, Ct" uniqKey="Gallo C">CT Gallo</name>
</author>
<author><name sortKey="Bertoni, M" uniqKey="Bertoni M">M Bertoni</name>
</author>
<author><name sortKey="Bordoli, L" uniqKey="Bordoli L">L Bordoli</name>
</author>
<author><name sortKey="Schwede, T" uniqKey="Schwede T">T Schwede</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Yang, J" uniqKey="Yang J">J Yang</name>
</author>
<author><name sortKey="Yan, R" uniqKey="Yan R">R Yan</name>
</author>
<author><name sortKey="Roy, A" uniqKey="Roy A">A Roy</name>
</author>
<author><name sortKey="Xu, D" uniqKey="Xu D">D Xu</name>
</author>
<author><name sortKey="Poisson, J" uniqKey="Poisson J">J Poisson</name>
</author>
<author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kallberg, M" uniqKey="Kallberg M">M Kallberg</name>
</author>
<author><name sortKey="Wang, H" uniqKey="Wang H">H Wang</name>
</author>
<author><name sortKey="Wang, S" uniqKey="Wang S">S Wang</name>
</author>
<author><name sortKey="Peng, J" uniqKey="Peng J">J Peng</name>
</author>
<author><name sortKey="Wang, Z" uniqKey="Wang Z">Z Wang</name>
</author>
<author><name sortKey="Lu, H" uniqKey="Lu H">H Lu</name>
</author>
<author><name sortKey="Xu, J" uniqKey="Xu J">J Xu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jo, S" uniqKey="Jo S">S Jo</name>
</author>
<author><name sortKey="Kim, T" uniqKey="Kim T">T Kim</name>
</author>
<author><name sortKey="Iyer, Vg" uniqKey="Iyer V">VG Iyer</name>
</author>
<author><name sortKey="Im, W" uniqKey="Im W">W Im</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Van Meer, G" uniqKey="Van Meer G">G van Meer</name>
</author>
<author><name sortKey="Voelker, Dr" uniqKey="Voelker D">DR Voelker</name>
</author>
<author><name sortKey="Feigenson, Gw" uniqKey="Feigenson G">GW Feigenson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Adams, Pd" uniqKey="Adams P">PD Adams</name>
</author>
<author><name sortKey="Afonine, Pv" uniqKey="Afonine P">PV Afonine</name>
</author>
<author><name sortKey="Bunkoczi, G" uniqKey="Bunkoczi G">G Bunkoczi</name>
</author>
<author><name sortKey="Chen, Vb" uniqKey="Chen V">VB Chen</name>
</author>
<author><name sortKey="Davis, Iw" uniqKey="Davis I">IW Davis</name>
</author>
<author><name sortKey="Echols, N" uniqKey="Echols N">N Echols</name>
</author>
<author><name sortKey="Headd, Jj" uniqKey="Headd J">JJ Headd</name>
</author>
<author><name sortKey="Hung, Lw" uniqKey="Hung L">LW Hung</name>
</author>
<author><name sortKey="Kapral, Gj" uniqKey="Kapral G">GJ Kapral</name>
</author>
<author><name sortKey="Grosse Kunstleve, Rw" uniqKey="Grosse Kunstleve R">RW Grosse-Kunstleve</name>
</author>
<author><name sortKey="Mccoy, Aj" uniqKey="Mccoy A">AJ McCoy</name>
</author>
<author><name sortKey="Moriarty, Nw" uniqKey="Moriarty N">NW Moriarty</name>
</author>
<author><name sortKey="Oeffner, R" uniqKey="Oeffner R">R Oeffner</name>
</author>
<author><name sortKey="Read, Rj" uniqKey="Read R">RJ Read</name>
</author>
<author><name sortKey="Richardson, Dc" uniqKey="Richardson D">DC Richardson</name>
</author>
<author><name sortKey="Richardson, Js" uniqKey="Richardson J">JS Richardson</name>
</author>
<author><name sortKey="Terwilliger, Tc" uniqKey="Terwilliger T">TC Terwilliger</name>
</author>
<author><name sortKey="Zwart, Ph" uniqKey="Zwart P">PH Zwart</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Romero Brey, I" uniqKey="Romero Brey I">I Romero-Brey</name>
</author>
<author><name sortKey="Bartenschlager, R" uniqKey="Bartenschlager R">R Bartenschlager</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Australie</li>
<li>France</li>
</country>
<region><li>Bade-Wurtemberg</li>
<li>District de Karlsruhe</li>
<li>Nouvelle-Galles du Sud</li>
</region>
<settlement><li>Heidelberg</li>
<li>Sydney</li>
</settlement>
</list>
<tree><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Doerflinger, Sylvie Y" sort="Doerflinger, Sylvie Y" uniqKey="Doerflinger S" first="Sylvie Y." last="Doerflinger">Sylvie Y. Doerflinger</name>
</region>
<name sortKey="Bartenschlager, Ralf" sort="Bartenschlager, Ralf" uniqKey="Bartenschlager R" first="Ralf" last="Bartenschlager">Ralf Bartenschlager</name>
<name sortKey="Bartenschlager, Ralf" sort="Bartenschlager, Ralf" uniqKey="Bartenschlager R" first="Ralf" last="Bartenschlager">Ralf Bartenschlager</name>
<name sortKey="Cortese, Mirko" sort="Cortese, Mirko" uniqKey="Cortese M" first="Mirko" last="Cortese">Mirko Cortese</name>
<name sortKey="Doerflinger, Sylvie Y" sort="Doerflinger, Sylvie Y" uniqKey="Doerflinger S" first="Sylvie Y." last="Doerflinger">Sylvie Y. Doerflinger</name>
<name sortKey="Doerflinger, Sylvie Y" sort="Doerflinger, Sylvie Y" uniqKey="Doerflinger S" first="Sylvie Y." last="Doerflinger">Sylvie Y. Doerflinger</name>
<name sortKey="Hansman, Grant S" sort="Hansman, Grant S" uniqKey="Hansman G" first="Grant S." last="Hansman">Grant S. Hansman</name>
<name sortKey="Hansman, Grant S" sort="Hansman, Grant S" uniqKey="Hansman G" first="Grant S." last="Hansman">Grant S. Hansman</name>
<name sortKey="Lohmann, Volker" sort="Lohmann, Volker" uniqKey="Lohmann V" first="Volker" last="Lohmann">Volker Lohmann</name>
<name sortKey="Menne, Zach" sort="Menne, Zach" uniqKey="Menne Z" first="Zach" last="Menne">Zach Menne</name>
<name sortKey="Romero Brey, Ines" sort="Romero Brey, Ines" uniqKey="Romero Brey I" first="Inés" last="Romero-Brey">Inés Romero-Brey</name>
<name sortKey="Schenk, Christian" sort="Schenk, Christian" uniqKey="Schenk C" first="Christian" last="Schenk">Christian Schenk</name>
</country>
<country name="France"><noRegion><name sortKey="Tubiana, Thibault" sort="Tubiana, Thibault" uniqKey="Tubiana T" first="Thibault" last="Tubiana">Thibault Tubiana</name>
</noRegion>
<name sortKey="Bressanelli, Stephane" sort="Bressanelli, Stephane" uniqKey="Bressanelli S" first="Stéphane" last="Bressanelli">Stéphane Bressanelli</name>
</country>
<country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="White, Peter A" sort="White, Peter A" uniqKey="White P" first="Peter A." last="White">Peter A. White</name>
</region>
</country>
</tree>
</affiliations>
</record>
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